Historically, mpox has been a zoonotic disease with little human-to-human transmission. However, the virus is showing signs of microevolution. In fact, a new virus clade reported in Africa has pandemic potential. The WHO and Africa CDC's failure to provide vaccines and financial resources as soon as the outbreak was identified has cost the world the opportunity to cut mpox's transmission chain.
The mpox virus is spreading. However, international support has been mobilized, and significant strides have been made to contain the outbreak. Thanks to Africa CDC's proactive approach, the WHO's financial support, increased flow of medical supplies into affected areas, and the manufacturing of vaccines in Africa, the continent is on course to address and overcome the epidemic's public health challenges.