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Brain-guided fever therapy has achieved the first documented total reversal of ALS, with a confirmation of the disappearance of motor neuron death and complete restoration of function. The patient went from nonverbal and unable to walk to swimming, golfing and living normally. This breakthrough modernizes Nobel Prize-winning science with AI precision, offering hope for millions suffering from neurological diseases, even beyond ALS, such as Alzheimer's, Parkinson's, and other diseases rooted in disrupted brain protein clearance.
A single patient case report cannot establish that brain temperature therapy reverses ALS. This study lacks a control group, cannot rule out misdiagnosis or natural fluctuations and uses a device only FDA-cleared as a thermometer. The comparison to Nobel Prize-winning fever therapy ignores that treatment killed up to 20% of patients and was abandoned for safer alternatives. Until controlled clinical trials validate safety and efficacy, claims of ALS reversal and broader disease applications remain unproven.